09 JUN


UK Biobank Seminar - Extending UKBiobank's reach into the mitochondrial genome (mtDNA)

The first in a series of seminars organised by N8 CIR to help researchers learn more about this vital resource.

Online Event
9 Jun 2021 10 a.m. — 11 a.m.

Chair: Prof Christopher Yau, Professor of Artificial Intelligence, University of Manchester
Extending UKBiobank's reach into the mitochondrial genome (mtDNA)
Speaker – Emma Drummond, Lancaster University

Emma Drummond has developed a novel interpolation route which links microarray data to open-source libraries of full mtDNA sequence. Mitochondria are the cell organelle relied upon to provide ATP for all eukaryotic cells, which they must do efficiently and responsively.

The UKBiobank has collected a volume of data which enables an exploration of the human mitochondrial genome (mtDNA) for variants influencing mitochondrial performance. However, the density of the genetic data requires imputation, interpolating from known data points. Current methods fail to fully exploit what is known about the mtDNA and its inheritance pattern, which Drummond has improved upon.

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